Run Msconfig. Select the General tab and click on selective Startup. Clear the boxes for Load Config.sys and Load Autoexec.bat. Click Apply, then Ok, restart the computer when prompted.
Both the Config.sys and the Autoexec.bat are legacy files and are not needed to run Windows.
Also click on System in the Control Panel and select the Device Manager tab. Scroll down to CD_ROM and double click on it. Remove the Device therein and restart the computer.
Windows will redetect the device and load the drivers thereby.