I hope some of this helps:
Solution ID: 16241
Some third-party conduits not compatible with Palm Desktop 4.x (Macintosh)
Third-party conduits that worked with previous versions of Palm Desktop and HotSync® Manager may not work with Palm Desktop software 4.x.
Please check with the respective software developer for updated conduits. In Mac OS X, conduits must be updated by the conduit developer to work in Mac OS X. In Mac OS 9, the Palm Setup Assistant moves conduits to the new location (Mac HD : System Folder : Application Support : Palm HotSync : Conduits). Please report any problems to the conduit developer.
There are a few known issues with Palm Desktop and HotSync Manager 4.0 for Macintosh.
* Mac OS X 10.1.3 is required to enable infrared (IR) HotSync operations. However, IR synchronization is only supported on Titanium PowerBooks and G3 PowerBooks with Firewire (Pismo).
* Mac OS X 10.1.x does not enable you to perform HotSync operations while using serial ports (This only affects older Macs that do not have USB ports, and for which Apple supports installing Mac OS X, like the beige G3 tower). Check the documentation for your release of Mac OS X to find out if this situation has changed.
* Mac OS X 10.1.x does not support the dialing of Address Book phone numbers through a modem. You can dial phone numbers using the speaker. See the built-in Palm Desktop help file for more information (use the "Help" menu item from within Palm Desktop).
* Mac OS X supports UFS formatting of hard drives. However, Palm Desktop and HotSync Manager 4.0 for Macintosh does not support installation on UFS formatted hard drives.
* The Palm Desktop and HotSync Manager 4.0 installer will not work if an NFS volume is mounted. Dismount all NFS volumes and then run the installer.
* The "Instant Palm Desktop" application is not available in Mac OS 9 until you first launch the Palm Desktop software and open a User Data file.
* You cannot successfully initiate a HotSync operation while the Macintosh is in Sleep Mode. If using the modem synchronization feature in HotSync Manager, ensure that your Macintosh is set not to go to sleep.
* If you use a Serial to USB adapter other than the one distributed by Palm (e.g. Keyspan USB adapter), it must be plugged in at startup and continue to be used in the same USB port.
* If, after restarting your computer, you are unable to perform a USB HotSync operation, unplug the USB cable from your computer, and then plug the cable back in. This re-establishes communication with the HotSync software. Take note of the known issue directly above (serial to USB adapter).
* AppleScript 1.7, which comes with Mac OS 9.2.2, causes a crash when you use the E-mail or Web buttons in the Address Detail card. Currently, no AppleScript update is available to address this issue. To resolve this problem, revert back to AppleScript 1.6.